Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk?

Controversy over fat quality and cardiovascular disease risk stems from a series of meta-analyses prospective cohort randomised intervention trials, which found little evidence for significant relationship between the intake saturated endpoints. Possible explanations these null findings include difficulties inherent in estimating true food intake, confounding effects macronutrient replacement composition, marked inter-individual variation response serum LDL-cholesterol. The aim this narrative review was to present existence origins LDL-cholesterol dietary fat, its potential explain controversy latter. provides suggest that LDL-responsiveness may harbour confound atherosclerotic risk, thus undermining effectiveness guideline replace with unsaturated fat. It concludes identification application simple biomarker phenomenon, would make it possible tailor guidelines LDL responsive individuals, who stand gain greater benefit their health.